Having noticed that Apple quietly removed Reset the Bluetooth module option: -
in macOS 12 Monterey, I was pleased to "discover" that there is the "nuclear" option of kill the Bluetooth stack, via: -
sudo pkill bluetoothd
before rebooting.
For the record, I have NOT yet tried this, but I trust the source of this tip, namely 9to5mac.com : -
But, of course, YMMV
There's also this: -
from Apple themselves